thymidylatesynthaseinhibitor

由 L Costantino 著作 · 2022 · 被引用 3 次 — Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy.

由 X Li 著作 · 2020 · 被引用 11 次 — Objectives. Our research hopes to develop a TS inhibitor that is more effective than the current first-line clinical treatment of pemetrexed ...

由 X Li 著作 · 2019 · 被引用 15 次 — Thymidylate synthase (TS) is a hot target for tumor chemotherapy, and its inhibitors are an essential direction for anti-tumor drug research ...

由 AL Jackman 著作 · 1995 · 被引用 237 次 — The thymidylate synthase inhibitor ICI D1694 is superior to CB3717, 5-fluorouracil and methotrexate against a panel of human tumour xenografts. Proc Am Assoc ...

Inhibitor, 99.98%. Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis.

This drug is transported into the cells by the reduced folate carrier (RFC), and its terminal glutamate residue is converted into a polyglutamate by ...

由 PV Danenberg 著作 · 1999 · 被引用 119 次 — Abstract. Thymidylate synthase (TS) is a critical enzyme for DNA replication and cell growth because it is the only de novo source of thymine nucleotide ...

Thymidylate synthetase inhibitors are folate-based potential anticancer chemotherapy medications and a nucleoside analog that work by inhibiting the enzyme ...